Zidovudine use in pregnancy and congenital malformations

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Congenital malformations and environmental influences in pregnancy.

Most human congenital malformations are believed to be due to the interaction of both genetic and environmental influences. Neither retrospective enquiry (e.g., Record, 1958) nor prospective study (e.g., McDonald, 1961) has yet been of much value in uncovering the environmental factors responsible and, with the exception of maternal rubella infection and a small number of drugs (notably thalido...

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Hormonal pregnancy tests and congenital malformations.

I have read with interest Dr. D.T. Janerich's article (April 23, p. 1058) confirming the teratological effect of hormonal pregnancy tests and other exogenous sex hormone preparations in relation to congenital heart diseases. The discovery of the teratological effect of hormonal pregnancy tests emerged from my studies into central nervous system malformations in 1967. In this and in further pu...

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Maternal Asthma and Use of Antiasthmatic Drugs in Early Pregnancy and Congenital Malformations in the Offspring

Objectives: To investigate the risk of congenital malformations in infants born of women who had used antiasthmatic drugs in early pregnancy. Methods: Data were obtained from the Swedish Medical Birth Register for 1996-2011. Information on drug use was based on midwife interviews towards the end of the first trimester. Presence of congenital malformations was ascertained from three national hea...

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Maternal Hypothyroidism in Early Pregnancy and Infant Structural Congenital Malformations

Background. The question is debated on whether maternal hypothyroidism or use of thyroxin in early pregnancy affects the risk for infant congenital malformations. Objectives. To expand the previously published study on maternal thyroxin use in early pregnancy and the risk for congenital malformations. Methods. Data from the Swedish Medical Birth Register were used for the years 1996-2011 and in...

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Smoking habits, nicotine use, and congenital malformations.

OBJECTIVE We examined whether maternal smoking and use of nicotine substitutes during the first 12 weeks of pregnancy increased the prevalence of congenital malformations in general and of certain congenital malformations in particular. METHODS In the Danish National Birth Cohort (1997-2003) we identified 76,768 pregnancies (and their subsequent singleton births); 20,603 were exposed to tobac...

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ژورنال

عنوان ژورنال: AIDS

سال: 2017

ISSN: 0269-9370

DOI: 10.1097/qad.0000000000001549